Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis

Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis

Rheumatoid arthritis (RA) is among the most prevalent forms of autoimmunity. Gentiopicroside (Gent) is an iridoid glucoside derived from the Gentiana Macrophylla Pall which is used in traditional Chinese medicine to treat RA. The present study was designed to explore the ability of Gent to combat RA...

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Bibliographic Details
Main Authors: Meiling Wang, Hongyan Li, Yanfang Wang, Yanfei Hao, Yanan Huang, Xinlin Wang, Yongying Lu, Yuan Du, Fenghua Fu, Wenyu Xin, Leiming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
gentiopicroside
adjuvant-induced arthritis
rheumatoid arthritis fibroblast-like synoviocytes
reactive oxygen species
nuclear factor-kappa B
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00515/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00515/full

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