Pediatric Anaplastic Embryonal Rhabdomyosarcoma: Targeted Therapy Guided by Genetic Analysis and a Patient-Derived Xenograft Study

Pediatric Anaplastic Embryonal Rhabdomyosarcoma: Targeted Therapy Guided by Genetic Analysis and a Patient-Derived Xenograft Study

Therapy for rhabdomyosarcoma (RMS) has generally been limited to combinations of conventional cytotoxic agents similar to regimens originally developed in the late 1960s. Recently, identification of molecular alterations through next-generation sequencing of individual tumor specimens has facilitate...

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Bibliographic Details
Main Authors: Stuart L. Cramer, Aubrey L. Miller, Joseph G. Pressey, Tracy L. Gamblin, Elizabeth A. Beierle, Brian D. Kulbersh, Patrick L. Garcia, Leona N. Council, Rupa Radhakrishnan, Skyler V. Hendrix, David R. Kelly, Raymond G. Watts, Karina J. Yoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Oncology
Subjects:
anaplastic embryonal rhabdomyosarcoma
patient-derived xenograft
case study
vorinostat
targeted therapy
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00327/full

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http://journal.frontiersin.org/article/10.3389/fonc.2017.00327/full

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