Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules

Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules

Abstract Background Genetic engineering of T-cells to express specific T cell receptors (TCR) has emerged as a novel strategy to treat various malignancies. More widespread utilization of these types of therapies has been somewhat constrained by the lack of closed culture processes capable of expand...

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Bibliographic Details
Main Authors: Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek, Steven L. Highfill
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Translational Medicine
Subjects:
E6 HPV
E7 HPV
HPV-16+
T-cell receptor
Cellular therapy
Cancer immunotherapy
Online Access:http://link.springer.com/article/10.1186/s12967-018-1384-z

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http://link.springer.com/article/10.1186/s12967-018-1384-z

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