Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models

Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models

Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based app...

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Main Authors: Olusegun J. Ilegbusi, Zhiliang Li, Behnaz Seyfi, Yugang Min, Sanford Meeks, Patrick Kupelian, Anand P. Santhanam
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Biomedical Imaging
Online Access:http://dx.doi.org/10.1155/2012/350853
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spelling doaj-f96ddf25acf44cdd85c2a5c1f6a7df102020-11-24T22:19:40ZengHindawi LimitedInternational Journal of Biomedical Imaging1687-41881687-41962012-01-01201210.1155/2012/350853350853Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung ModelsOlusegun J. Ilegbusi0Zhiliang Li1Behnaz Seyfi2Yugang Min3Sanford Meeks4Patrick Kupelian5Anand P. Santhanam6Department of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USADepartment of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USADepartment of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USADepartment of Radiation Oncology, University of California, Los Angeles, CA 90230, USADepartment of Radiation Oncology, M.D. Anderson Cancer Center Orlando, Orlando, FL 32806 , USADepartment of Radiation Oncology, University of California, Los Angeles, CA 90230, USADepartment of Radiation Oncology, University of California, Los Angeles, CA 90230, USALung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.http://dx.doi.org/10.1155/2012/350853
collection DOAJ
language English
format Article
sources DOAJ
author Olusegun J. Ilegbusi
Zhiliang Li
Behnaz Seyfi
Yugang Min
Sanford Meeks
Patrick Kupelian
Anand P. Santhanam
spellingShingle Olusegun J. Ilegbusi
Zhiliang Li
Behnaz Seyfi
Yugang Min
Sanford Meeks
Patrick Kupelian
Anand P. Santhanam
Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
International Journal of Biomedical Imaging
author_facet Olusegun J. Ilegbusi
Zhiliang Li
Behnaz Seyfi
Yugang Min
Sanford Meeks
Patrick Kupelian
Anand P. Santhanam
author_sort Olusegun J. Ilegbusi
title Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
title_short Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
title_full Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
title_fullStr Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
title_full_unstemmed Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models
title_sort modeling airflow using subject-specific 4dct-based deformable volumetric lung models
publisher Hindawi Limited
series International Journal of Biomedical Imaging
issn 1687-4188
1687-4196
publishDate 2012-01-01
description Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.
url http://dx.doi.org/10.1155/2012/350853
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AT zhiliangli modelingairflowusingsubjectspecific4dctbaseddeformablevolumetriclungmodels
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AT yugangmin modelingairflowusingsubjectspecific4dctbaseddeformablevolumetriclungmodels
AT sanfordmeeks modelingairflowusingsubjectspecific4dctbaseddeformablevolumetriclungmodels
AT patrickkupelian modelingairflowusingsubjectspecific4dctbaseddeformablevolumetriclungmodels
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