Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER) are central contributors to neurodegenerative diseases. The unfolded protein respo...

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Bibliographic Details
Main Authors: Paulina García-González, Felipe Cabral-Miranda, Claudio Hetz, Fabiola Osorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
UPR
neurodegeneration
immune system
inflammation
protein protein misfolding diseases
ER stress
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02541/full

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