Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability

Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability

Abstract Background Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the productivity of CHO cells. Executive caspases, including caspases 3 and 7...

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Bibliographic Details
Main Authors: Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed, Hesam Dehghani
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Biological Research
Subjects:
CHO cells
Apoptosis
CRISPR-associated protein 9
Caspase 7
Cell proliferatio
Online Access:http://link.springer.com/article/10.1186/s40659-020-00319-x

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