The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu

<p>Abstract</p> <p>Background</p> <p>The Human Immunodeficiency virus type 1 (HIV-1) Vpu protein enhances virus release from infected cells and induces proteasomal degradation of CD4. Recent work identified BST-2/CD317 as a host factor that inhibits HIV-1 virus release...

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Bibliographic Details
Main Authors: Strebel Klaus, Kao Sandra, Miyagi Eri, Andrew Amy J
Format: Article
Language:English
Published: BMC 2009-09-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/6/1/80