Minimalistic In Vitro Culture to Drive Human Naive B Cell Differentiation into Antibody-Secreting Cells

Minimalistic In Vitro Culture to Drive Human Naive B Cell Differentiation into Antibody-Secreting Cells

High-affinity antibody-secreting cells (ASC) arise from terminal differentiation of B-cells after coordinated interactions with T follicular helper (Tfh) cells in germinal centers (GC). Elucidation of cues promoting human naive B-cells to progress into ASCs is challenging, as this process is notorio...

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Bibliographic Details
Main Authors:	Peter-Paul A. Unger, Niels J. M. Verstegen, Casper Marsman, Tineke Jorritsma, Theo Rispens, Anja ten Brinke, S. Marieke van Ham
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Cells
Subjects:	costimulatory molecules cytokines cell differentiation transcription factors
Online Access:	https://www.mdpi.com/2073-4409/10/5/1183

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