Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction with parallel fiber activity, a pairing that enhanc...

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Bibliographic Details
Main Authors: Michael A Gaffield, Matthew J M Rowan, Samantha B Amat, Hirokazu Hirai, Jason M Christie
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
cerebellum
inhibition
calcium
Online Access:https://elifesciences.org/articles/36246

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