Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model

Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model

Abstract Background Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signaling pathway network involved in CSC division remains elusive. FXR (Far...

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Bibliographic Details
Main Authors: Mi Chen, Chenxia Lu, Hanwen Lu, Junyi Zhang, Dan Qin, Shenghui Liu, Xiaodong Li, Lisheng Zhang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Stem Cell Research & Therapy
Subjects:
FXR
Symmetric cell division
Sox9
Liver cancer stem cell
Notch1
Online Access:https://doi.org/10.1186/s13287-021-02298-6

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