A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs

A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs

We have identified a novel archaeal protein that apparently plays two distinct roles in ribosome metabolism. It is a polypeptide of about 18 kDa (termed Rbp18) that binds free cytosolic C/D box sRNAs in vivo and in vitro and behaves as a structural ribosomal protein, specifically a component of the...

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Main Authors: Andrea Ciammaruconi, Stefania Gorini, Paola Londei
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Archaea
Online Access:http://dx.doi.org/10.1155/2008/472786
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spelling doaj-f9314a9db6d54a8f801bbc24e719e2bb2021-07-02T08:30:16ZengHindawi LimitedArchaea1472-36461472-36542008-01-012315115810.1155/2008/472786A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAsAndrea Ciammaruconi0Stefania Gorini1Paola Londei2Dpt. Biotecnologie Cellulari ed Ematologia, Università di Roma “La Sapienza” (Policlinico) Viale Regina Elena 324, 00161 Rome, ItalyDpt. Biotecnologie Cellulari ed Ematologia, Università di Roma “La Sapienza” (Policlinico) Viale Regina Elena 324, 00161 Rome, ItalyDpt. Biotecnologie Cellulari ed Ematologia, Università di Roma “La Sapienza” (Policlinico) Viale Regina Elena 324, 00161 Rome, ItalyWe have identified a novel archaeal protein that apparently plays two distinct roles in ribosome metabolism. It is a polypeptide of about 18 kDa (termed Rbp18) that binds free cytosolic C/D box sRNAs in vivo and in vitro and behaves as a structural ribosomal protein, specifically a component of the 30S ribosomal subunit. As Rbp18 is selectively present in Crenarcheota and highly thermophilic Euryarchaeota, we propose that it serves to protect C/D box sRNAs from degradation and perhaps to stabilize thermophilic 30S subunits.http://dx.doi.org/10.1155/2008/472786
collection DOAJ
language English
format Article
sources DOAJ
author Andrea Ciammaruconi
Stefania Gorini
Paola Londei
spellingShingle Andrea Ciammaruconi
Stefania Gorini
Paola Londei
A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
Archaea
author_facet Andrea Ciammaruconi
Stefania Gorini
Paola Londei
author_sort Andrea Ciammaruconi
title A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
title_short A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
title_full A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
title_fullStr A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
title_full_unstemmed A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs
title_sort bifunctional archaeal protein that is a component of 30s ribosomal subunits and interacts with c/d box small rnas
publisher Hindawi Limited
series Archaea
issn 1472-3646
1472-3654
publishDate 2008-01-01
description We have identified a novel archaeal protein that apparently plays two distinct roles in ribosome metabolism. It is a polypeptide of about 18 kDa (termed Rbp18) that binds free cytosolic C/D box sRNAs in vivo and in vitro and behaves as a structural ribosomal protein, specifically a component of the 30S ribosomal subunit. As Rbp18 is selectively present in Crenarcheota and highly thermophilic Euryarchaeota, we propose that it serves to protect C/D box sRNAs from degradation and perhaps to stabilize thermophilic 30S subunits.
url http://dx.doi.org/10.1155/2008/472786
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