| Summary: | It aimed to explore the application value of high-frequency ultrasound image based on the wavelet bilateral filtering algorithm in the repair evaluation of hypertrophic scar and keloid, as well as the expression change of nerve growth factor (NGF). 72 patients with scars admitted to hospital from October 2018 to October 2019 were chosen and classified as hypertrophic scar patients (group A) and keloid patients (group B), with 36 cases in each group. All patients received scar repair treatment, and another 30 normal skin volunteers (group C) were selected. High-frequency ultrasound images based on the wavelet bilateral filter algorithm were utilized for skin examination. The expression differences of NGF and pro-NGF in each group were measured by immunohistochemical staining and Western blot. The results showed that the denoising effect (signal-to-noise ratio (PSNR) = 33.2762), structural similarity (SSIM = 0.8963), and edge similarity (FoM = 0.2975) of the proposed algorithm were better than those of bilateral filtering and wavelet soft-threshold algorithms. The skin thickness of groups A and B was considerably higher relative to that of group C (P < 0.05), but the echo intensity of the skin dermis of groups A and B was evidently inferior to that of group C (P < 0.05). The results of immunohistochemistry showed that in contrast to group C, the average optical density of NGF in groups A and B increased remarkably (P < 0.01). In contrast to group C, the positive expression of pro-NGF in groups A and B was notably reduced (P < 0.05). Western blot results showed that relative to group C, the expression of NGF protein in groups A and B was increased greatly (P < 0.01), but the expression of pro-NGF protein in groups A and B was reduced (P < 0.01). The results suggested that the wavelet bilateral filter algorithm can be adopted to evaluate pathological skin scars, and pathological skin scar formation was closely related to the expression levels of NGF and pro-NGF.
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