Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.

Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.

Gliotoxin, and other related molecules, are encoded by multi-gene clusters and biosynthesized by fungi using non-ribosomal biosynthetic mechanisms. Almost universally described in terms of its toxicity towards mammalian cells, gliotoxin has come to be considered as a component of the virulence arsen...

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Bibliographic Details
Main Authors: Markus Schrettl, Stephen Carberry, Kevin Kavanagh, Hubertus Haas, Gary W Jones, Jennifer O'Brien, Aine Nolan, John Stephens, Orla Fenelon, Sean Doyle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20548963/pdf/?tool=EBI

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