Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity

Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity

Aberrant Sumoylation-mediated protein dysfunction is involved in a variety of oxidative and aging pathologies. We previously reported that Sumoylation-deficient Prdx6K<sup>(lysine)122/142R(Arginine)</sup> linked to the TAT-transduction domain gained stability and protective efficacy. In...

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Bibliographic Details
Main Authors: Bhavana Chhunchha, Eri Kubo, Uday B. Kompella, Dhirendra P. Singh
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
peroxiredoxin 6
transduction domain
oxidative stress
antioxidants
nano-formulation
nanoparticles
Online Access:https://www.mdpi.com/2076-3921/10/8/1245

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