Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence

In transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, s...

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Main Authors:	Jasper Iske, Tomohisa Matsunaga, Hao Zhou, Stefan G. Tullius
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Immunology
Subjects:	immunosenescence and inflammaging immunosenescence immune aging senescent cell passenger leukocytes senescent associated secretory phenotype
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.671479/full

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record_format	Article
spelling	doaj-f910746e3a0243729e28fe20d69a44a82021-04-28T05:21:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.671479671479Donor and Recipient Age-Mismatches: The Potential of Transferring SenescenceJasper Iske0Tomohisa Matsunaga1Tomohisa Matsunaga2Hao Zhou3Stefan G. Tullius4Division of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Urology, Osaka Medical College, Osaka, JapanDivision of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesIn transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, soluble molecules as part of their distinct secretory phenotype that have been shown to drive senescence and age-related co-morbidities. Preliminary own data show that the transplantation of old organs limits the physical reserve of recipient animals. Here, we review how organ age may affect transplant recipients and discuss the potential of accelerated aging.https://www.frontiersin.org/articles/10.3389/fimmu.2021.671479/fullimmunosenescence and inflammagingimmunosenescenceimmune agingsenescent cellpassenger leukocytessenescent associated secretory phenotype
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jasper Iske Tomohisa Matsunaga Tomohisa Matsunaga Hao Zhou Stefan G. Tullius
spellingShingle	Jasper Iske Tomohisa Matsunaga Tomohisa Matsunaga Hao Zhou Stefan G. Tullius Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence Frontiers in Immunology immunosenescence and inflammaging immunosenescence immune aging senescent cell passenger leukocytes senescent associated secretory phenotype
author_facet	Jasper Iske Tomohisa Matsunaga Tomohisa Matsunaga Hao Zhou Stefan G. Tullius
author_sort	Jasper Iske
title	Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
title_short	Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
title_full	Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
title_fullStr	Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
title_full_unstemmed	Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
title_sort	donor and recipient age-mismatches: the potential of transferring senescence
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2021-04-01
description	In transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, soluble molecules as part of their distinct secretory phenotype that have been shown to drive senescence and age-related co-morbidities. Preliminary own data show that the transplantation of old organs limits the physical reserve of recipient animals. Here, we review how organ age may affect transplant recipients and discuss the potential of accelerated aging.
topic	immunosenescence and inflammaging immunosenescence immune aging senescent cell passenger leukocytes senescent associated secretory phenotype
url	https://www.frontiersin.org/articles/10.3389/fimmu.2021.671479/full
work_keys_str_mv	AT jasperiske donorandrecipientagemismatchesthepotentialoftransferringsenescence AT tomohisamatsunaga donorandrecipientagemismatchesthepotentialoftransferringsenescence AT tomohisamatsunaga donorandrecipientagemismatchesthepotentialoftransferringsenescence AT haozhou donorandrecipientagemismatchesthepotentialoftransferringsenescence AT stefangtullius donorandrecipientagemismatchesthepotentialoftransferringsenescence
_version_	1721505142119858176

Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence

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