Histiocytosis-X: role of histology and S-100 protein in grading the severity of disease.

Histiocytosis-X: role of histology and S-100 protein in grading the severity of disease.

Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied...

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Bibliographic Details
Main Authors: Sane S, Nainaney K
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 1990-01-01
Series:Journal of Postgraduate Medicine
Subjects:
Child
Preschool
Female
Histiocytosis
Langerhans-Cell
metabolism
pathology
Human
Immunohistochemistry
Infant
Newborn
Male
S100 Proteins
analysis
Support
Non-U.S. Gov′t
Online Access:http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1990;volume=36;issue=1;spage=16;epage=9;aulast=Sane
Description
Summary:Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied by immunoperoxidase method. Our results indicate that diagnosis of histiocytosis-X necessitates histological confirmation but grading of histological criteria and S-100 positivity do not allow prediction of severity and extent of the disease.
ISSN:0022-3859
0972-2823

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