Increased metallothionein I/II expression in patients with temporal lobe epilepsy.

Increased metallothionein I/II expression in patients with temporal lobe epilepsy.

In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepti...

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Main Authors: José Eduardo Peixoto-Santos, Orfa Yineth Galvis-Alonso, Tonicarlo Rodrigues Velasco, Ludmyla Kandratavicius, João Alberto Assirati, Carlos Gilberto Carlotti, Renata Caldo Scandiuzzi, Luciano Neder Serafini, João Pereira Leite
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3445538?pdf=render

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