Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts

Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts

The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochas...

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Main Authors: Marco Antoniotti, Giulio Caravagna, Alex Graudenzi, Giovanni de Matteis
Format: Article
Language:English
Published: Open Publishing Association 2013-09-01
Series:Electronic Proceedings in Theoretical Computer Science
Online Access:http://arxiv.org/pdf/1309.7693v1
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spelling doaj-f90104d9dddc465e97bee4c756ae24672020-11-25T00:14:02ZengOpen Publishing AssociationElectronic Proceedings in Theoretical Computer Science2075-21802013-09-01130Proc. Wivace 2013798210.4204/EPTCS.130.12Analysis of the spatial and dynamical properties of a multiscale model of intestinal cryptsMarco AntoniottiGiulio CaravagnaAlex GraudenziGiovanni de MatteisThe preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures. http://arxiv.org/pdf/1309.7693v1
collection DOAJ
language English
format Article
sources DOAJ
author Marco Antoniotti
Giulio Caravagna
Alex Graudenzi
Giovanni de Matteis
spellingShingle Marco Antoniotti
Giulio Caravagna
Alex Graudenzi
Giovanni de Matteis
Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
Electronic Proceedings in Theoretical Computer Science
author_facet Marco Antoniotti
Giulio Caravagna
Alex Graudenzi
Giovanni de Matteis
author_sort Marco Antoniotti
title Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
title_short Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
title_full Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
title_fullStr Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
title_full_unstemmed Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
title_sort analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
publisher Open Publishing Association
series Electronic Proceedings in Theoretical Computer Science
issn 2075-2180
publishDate 2013-09-01
description The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures.
url http://arxiv.org/pdf/1309.7693v1
work_keys_str_mv AT marcoantoniotti analysisofthespatialanddynamicalpropertiesofamultiscalemodelofintestinalcrypts
AT giuliocaravagna analysisofthespatialanddynamicalpropertiesofamultiscalemodelofintestinalcrypts
AT alexgraudenzi analysisofthespatialanddynamicalpropertiesofamultiscalemodelofintestinalcrypts
AT giovannidematteis analysisofthespatialanddynamicalpropertiesofamultiscalemodelofintestinalcrypts
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