Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease

Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease

Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the modeling of neurodegenerative diseases and pave the w...

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Bibliographic Details
Main Authors: Ferid Nassor, Rafika Jarray, Denis S. F. Biard, Auriane Maïza, Dulce Papy-Garcia, Serena Pavoni, Jean-Philippe Deslys, Frank Yates
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
stem cells
cerebral organoid
neurodegenerative disease
fronto-temporal dementia
Alzheimer
IPS
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00014/full

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