Accelerated apoptosis of neutrophils in familial Mediterranean fever

Accelerated apoptosis of neutrophils in familial Mediterranean fever

The causative mutations for familial Mediterranean fever (FMF) are located in the MEFV gene, which encodes pyrin. Pyrin modulates the susceptibility to apoptosis via its PYD domain but how the mutated versions of pyrin affect apoptotic processes is poorly understood. Spontaneous and induced rates of...

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Bibliographic Details
Main Authors: Gayane eManukyan, Rustam eAminov, Gagik eHakobyan, Tigran eDavtyan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Immunology
Subjects:
Apoptosis
Familial Mediterranean Fever
Neutrophils
Autoinflammation
whole blood
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00239/full

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