miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase

miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase

Olaparib has been used in the treatment of triple-negative breast cancer (TNBC) with BRCA mutations. In the present study, we demonstrated the effect of miR-27-3p on the γ-secretase pathway by regulating the sensitivity of TNBC cells to olaparib. miR-27-3p, a microRNA with the potential to target PS...

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Bibliographic Details
Main Authors: Meng Zhao, Baisheng Sun, Yan Wang, Gengbao Qu, Hua Yang, Pilin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
microRNA-27-3p
Notch pathway
triple-negative breast cancer
olaparib
γ-secretase
PSEN-1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.694491/full

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