Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from...

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Bibliographic Details
Main Authors: Simões Simone S., Medeiros Everaldo P., Gaião Edvaldo N., Lyra Wellington S., Moreira Pablo N. T., Araújo Mario C. U., Silva Edvan C., Nascimento Valberes B.
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2006-01-01
Series:Journal of the Brazilian Chemical Society
Subjects:
flow injection analysis
spectrophotometry
pharmaceuticals
metronidazole
nitrite
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028
Description
Summary:A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.
ISSN:0103-5053
1678-4790

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