Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells

Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells

Abstract Despite advances in glioblastoma (GBM) treatments, current approaches have failed to improve the overall survival of patients. The oncogene BMI-1, a core member of the polycomb group proteins, is a potential novel therapeutic target for GBM. To enhance the efficacy and reduce the toxicity,...

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Bibliographic Details
Main Authors: Elham Poonaki, Fatemeh Ariakia, Mohammad Jalili-Nik, Mehdi Shafiee Ardestani, Gholamhossein Tondro, Fariborz Samini, Sepideh Ghasemi, Sajad Sahab-Negah, Ali Gorji
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cancer Nanotechnology
Subjects:
Brain tumor
Metastasis
Nanoparticles
Scaffold
Cancer
Online Access:https://doi.org/10.1186/s12645-021-00078-8

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