β-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor.

β-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor.

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, regulating inflammatory and immune responses. MIF binds to cell surface receptor CD74, resulting in both rapid and sustained ERK activation. It was reported that MIF-induced rapid ERK activation requires its co-receptor CD44. Bu...

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Bibliographic Details
Main Authors: Lishi Xie, Xiaohang Qiao, Yanfang Wu, Jie Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3026819?pdf=render

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