Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection

• Main Authors: Mohamed MF, Seleem MN
• Format: Article
• Language: English
• Published: Dove Medical Press 2014-10-01
• Series: Drug Design, Development and Therapy
• Online Access: http://www.dovepress.com/efficacy-of-short-novel-antimicrobial-and-anti-inflammatory-peptides-i-peer-reviewed-article-DDDT

Mohamed F Mohamed, Mohamed N SeleemDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAAbstract: The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.Keywords: antimicrobial peptides, MRSA, lysostaphin, skin infection, mice