| Summary: | Although it has been a half-century since dioxin-contaminated herbicides were used to defoliate the landscape during the Vietnam War, dioxin contamination “hotspots„ still remain in Vietnam. Environmental and health impacts of these hotspots need to be evaluated. Intellectual disability (ID) is one of the diseases found in the children of people exposed to the herbicides. This study aims to identify genetic alterations of a patient whose family lived in a dioxin hotspot. The patient’s father had a highly elevated dioxin concentration. He was affected with undiagnosed moderate ID. To analyze de novo mutations and genetic variations, and to identify causal gene(s) for ID, we performed whole genome sequencing (WGS) of the proband and his parents. Two de novo missense mutations were detected, each one in <i>ETS2</i> and <i>ZNF408</i> genes, respectively. Compound heterozygosity was identified in <i>CENPF</i> and <i>TTN</i> genes. Existing knowledge on the genes and bioinformatics analyses suggest that <i>EST2</i>, <i>ZNF408</i>, and <i>CENPF</i> might be promising candidates for ID causative genes.
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