Effect of Oral Administration of Ethanolic Extracts of Propolis on Passive Avoidance Learning and Memory in Adult Male Mice
Background & objectives: Propolis is a natural product with powerful antioxidant and therapeutic effects. The aim of this study was to investigate the effect of propolis on passive avoidance memory in adult male mice. Methods: In this study, 40 adult male mice were divided into 8 groups, includ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Ardabil University of Medical Sciences
2017-04-01
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| Series: | Journal of Ardabil University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-54&slc_lang=en&sid=1 |
| Summary: | Background & objectives: Propolis is a natural product with powerful antioxidant and therapeutic effects. The aim of this study was to investigate the effect of propolis on passive avoidance memory in adult male mice.
Methods: In this study, 40 adult male mice were divided into 8 groups, including control, sham (solvent) and 3 treatment groups orally treated with 50, 100 and 200 mg/kg of propolis, respectively for two weeks before and one week after treatment. Then, passive avoidance learning and memory were recorded in timescales of 24 and 48 hours, 4 days and a week after shock by the shuttle box. Data were analyzed by ANOVA and Dunnett’s post hoc tests, and p<0.05 was considered significant.
Results: Administration of propolis (50 mg/kg) significantly increased the dark chamber entering time at intervals of 24 and 48 hours (p<0.001) and at concentrations of 100 and 200 mg/kg in all time periods after the shock (p<0.001).
Conclusion: Oral administrations of propolis can improve learning and memory dose-dependently in adult male mice. |
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| ISSN: | 2228-7280 2228-7299 |