Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface

Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface

Retinal gene delivery via intravitreal injection is hampered by various physiological barriers present in the eye of which the vitreoretinal (VR) interface represents the most serious hurdle. In this study, we present a retinal explant model especially designed to study the role of this interface as...

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Bibliographic Details
Main Authors: Karen Peynshaert, Joke Devoldere, Valérie Forster, Serge Picaud, Christian Vanhove, Stefaan C. De Smedt, Katrien Remaut
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
vitreoretinal interface
retinal gene delivery
inner limiting membrane
vitreous
retinal explant
ex vivo
large animal
nanoparticle
Online Access:http://dx.doi.org/10.1080/10717544.2017.1375578

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