World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis

World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis

Background: Following extensive, positive results in pre-clinical experiments, Bone Marrow Derived-Mesenchymal Stromal Cells (BM-MSCs) are now being tested as a novel therapy for ischemic stroke in ongoing clinical trials. However, multiple critical questions relating to their translational applicat...

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Bibliographic Details
Main Authors: Nikunj Satani, Chunyan Cai, Kaavya Giridhar, Daryl McGhiey, Sarah George, Kaushik Parsha, Duyen M. Nghiem, Krystal S. Valenzuela, Jenny Riecke, Farhaan S. Vahidy, Sean I. Savitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neurology
Subjects:
ischemic stroke
meta-analysis
functional outcome
mesenchymal stromal cells
treatment effect
timing of administration
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00405/full

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