2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-κB Phosphorylation and GDAP1L1/Drp1 Translocation

2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-κB Phosphorylation and GDAP1L1/Drp1 Translocation

Antrodia cinnamomea exhibits anti-inflammatory, antioxidant, and immunomodulatory activities. We aimed to explore the antipsoriatic potential of 2,4-dimethoxy-6-methylbenzene-1,3-diol (DMD) derived from A. cinnamomea. The macrophages activated by imiquimod (IMQ) were used as the cell model for exami...

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Bibliographic Details
Main Authors: Shih-Yi Chuang, Chi-Yuan Chen, Shih-Chun Yang, Ahmed Alalaiwe, Chih-Hung Lin, Jia-You Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Antrodia cinnamomea
2,4-dimethoxy-6-methylbenzene-1,3-diol
psoriasis
macrophage
GDAP1L1
Drp1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.664425/full

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