Effect of Shuxuetong injection on platelet function, hemorheology and cerebral blood flow in patients with ischemic stroke

• Main Authors: Ting-Gang Wang, Shu-Hua Gui, Mei-Qi Di
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-02-01
• Series: Journal of Hainan Medical University
• Subjects: Shuxuetong injection; Ischemic stroke; Platelet function; Hemorheology; Change of cerebral blood flow
• Online Access: http://www.hnykdxxb.com/PDF/201802/03.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the effect of Shuxuetong injection on platelet function, hemorheology and cerebral blood flow in patients with ischemic stroke. Methods: One hundred cases of ischemic stroke admitted in our hospital from February 2015 to January 2017 were randomly divided into control group and observation group. The control group was given routine treatment. The observation group was given Shuxuetong injection on the basis of the control group. The changes of platelet function, hemorheology and cerebral blood flow before and after treatment were detected in both groups. Results: After treatment, the whole blood viscosity, plasma viscosity and fibrinogen level in both groups were significantly lower than those before treatment. The whole blood viscosity, plasma viscosity and fibrinogen level in the observation group were (4.18±0.05) mPa•s, (1.66±0.12) mPa•s and (3.45±0.08) g/L, respectively, which were significantly lower than the control group; After treatment, the levels of MCA, ACA and PCA in both groups were significantly increased. MCA, ACA and PCA levels in the observation group were (70.82±4.13) cm/s, (60.62±3.55) cm/s and (54.11±2.36) cm/s, which were significantly higher than those in the control group; After treatment, the maximum platelet aggregation rate, PLT, MPV and PDW levels in the two groups significantly decreased. The maximum platelet aggregation rate, PLT, MPV and PDW levels in the observation group were (27.93±1.44)% and (155.32±13.46)伊109/L, (9.42±0.32) fL and (9.12±0.24) fL, respectively, which were significantly lower than those in the control group. Conclusions: Shuxuetong injection can effectively improve the patient’s hemorheology and platelet function, improve the level of cerebral blood flow in patients with significant effect, it is worth further clinical application.