An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes

An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes

High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate...

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Main Authors: Chindo Hicks, Ritika Ramani, Oliver Sartor, Ritu Bhalla, Lucio Miele, Zodwa Dlamini, Njabulo Gumede
Format: Article
Language:English
Published: SAGE Publishing 2017-03-01
Series:Biomarker Insights
Online Access:https://doi.org/10.1177/1177271917695810
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spelling doaj-f872e656e0e3462799ce264b3c17b5642020-11-25T02:41:33ZengSAGE PublishingBiomarker Insights1177-27192017-03-011210.1177/117727191769581010.1177_1177271917695810An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer PhenotypesChindo Hicks0Ritika Ramani1Oliver Sartor2Ritu Bhalla3Lucio Miele4Zodwa Dlamini5Njabulo Gumede6Department of Genetics, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USASimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USADepartment of Medicine, Tulane University, New Orleans, LA, USADepartment of Pathology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USADepartment of Genetics, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USADepartment of Biology, Mangosuthu University of Technology, Durban, South AfricaDepartment of Biology, Mangosuthu University of Technology, Durban, South AfricaHigh-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups. In addition, the analysis revealed molecular networks and biological pathways enriched for genetic susceptibility variants. The discovered pathways include the androgen, apoptosis, and insulinlike growth factor signaling pathways. This analysis established putative functional bridges between GWAS discoveries and the biological pathways involved in primary organ–confined and metastatic prostate cancer.https://doi.org/10.1177/1177271917695810
collection DOAJ
language English
format Article
sources DOAJ
author Chindo Hicks
Ritika Ramani
Oliver Sartor
Ritu Bhalla
Lucio Miele
Zodwa Dlamini
Njabulo Gumede
spellingShingle Chindo Hicks
Ritika Ramani
Oliver Sartor
Ritu Bhalla
Lucio Miele
Zodwa Dlamini
Njabulo Gumede
An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
Biomarker Insights
author_facet Chindo Hicks
Ritika Ramani
Oliver Sartor
Ritu Bhalla
Lucio Miele
Zodwa Dlamini
Njabulo Gumede
author_sort Chindo Hicks
title An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_short An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_full An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_fullStr An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_full_unstemmed An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_sort integrative genomics approach for associating genome-wide association studies information with localized and metastatic prostate cancer phenotypes
publisher SAGE Publishing
series Biomarker Insights
issn 1177-2719
publishDate 2017-03-01
description High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups. In addition, the analysis revealed molecular networks and biological pathways enriched for genetic susceptibility variants. The discovered pathways include the androgen, apoptosis, and insulinlike growth factor signaling pathways. This analysis established putative functional bridges between GWAS discoveries and the biological pathways involved in primary organ–confined and metastatic prostate cancer.
url https://doi.org/10.1177/1177271917695810
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