Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature

Molecular recognition of host/guest molecules represents the basis of many biological processes and phenomena. Enzymatic catalysis and inhibition, immunological response, reproduction of genetic information, biological regulatory functions, the effects of drugs, and ion transfer—all these processes...

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Main Authors:	Galina Mamardashvili, Nugzar Mamardashvili, Oscar Koifman
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Molecules
Subjects:	porphyrin receptor molecular recognition host–guest interactions binding cavities
Online Access:	https://www.mdpi.com/1420-3049/26/17/5292

id	doaj-f87269b459d746dabde7ce94c5f2be16
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spelling	doaj-f87269b459d746dabde7ce94c5f2be162021-09-09T13:53:25ZengMDPI AGMolecules1420-30492021-08-01265292529210.3390/molecules26175292Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different NatureGalina Mamardashvili0Nugzar Mamardashvili1Oscar Koifman2G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskayast. 1, 153045 Ivanovo, RussiaG.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskayast. 1, 153045 Ivanovo, RussiaG.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskayast. 1, 153045 Ivanovo, RussiaMolecular recognition of host/guest molecules represents the basis of many biological processes and phenomena. Enzymatic catalysis and inhibition, immunological response, reproduction of genetic information, biological regulatory functions, the effects of drugs, and ion transfer—all these processes include the stage of structure recognition during complexation. The goal of this review is to solicit and publish the latest advances in the design and sensing and binding abilities of porphyrin-based heterotopic receptors with well-defined geometries, the recognition ability of which is realized due to ionic, <i>H</i>-bridge, charge transfer, hydrophobic, and hydrophilic interactions. The dissection of the considered low-energy processes at the molecular scale expands our capabilities in the development of effective systems for controlled recognition, selective delivery, and prolonged release of substrates of different natures (including drugs) to their sites of functioning.https://www.mdpi.com/1420-3049/26/17/5292porphyrinreceptormolecular recognitionhost–guest interactionsbinding cavities
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Galina Mamardashvili Nugzar Mamardashvili Oscar Koifman
spellingShingle	Galina Mamardashvili Nugzar Mamardashvili Oscar Koifman Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature Molecules porphyrin receptor molecular recognition host–guest interactions binding cavities
author_facet	Galina Mamardashvili Nugzar Mamardashvili Oscar Koifman
author_sort	Galina Mamardashvili
title	Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature
title_short	Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature
title_full	Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature
title_fullStr	Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature
title_full_unstemmed	Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature
title_sort	macrocyclic receptors for identification and selective binding of substrates of different nature
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-08-01
description	Molecular recognition of host/guest molecules represents the basis of many biological processes and phenomena. Enzymatic catalysis and inhibition, immunological response, reproduction of genetic information, biological regulatory functions, the effects of drugs, and ion transfer—all these processes include the stage of structure recognition during complexation. The goal of this review is to solicit and publish the latest advances in the design and sensing and binding abilities of porphyrin-based heterotopic receptors with well-defined geometries, the recognition ability of which is realized due to ionic, <i>H</i>-bridge, charge transfer, hydrophobic, and hydrophilic interactions. The dissection of the considered low-energy processes at the molecular scale expands our capabilities in the development of effective systems for controlled recognition, selective delivery, and prolonged release of substrates of different natures (including drugs) to their sites of functioning.
topic	porphyrin receptor molecular recognition host–guest interactions binding cavities
url	https://www.mdpi.com/1420-3049/26/17/5292
work_keys_str_mv	AT galinamamardashvili macrocyclicreceptorsforidentificationandselectivebindingofsubstratesofdifferentnature AT nugzarmamardashvili macrocyclicreceptorsforidentificationandselectivebindingofsubstratesofdifferentnature AT oscarkoifman macrocyclicreceptorsforidentificationandselectivebindingofsubstratesofdifferentnature
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Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature

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