Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

Increased urinary albumin excretion is not simply an aftermath of glomerular injury, but is also involved in the progression of diabetic nephropathy (DN). Whereas Toll-like receptors (TLRs) are incriminated in the renal inflammation of DN, whether and how albumin is involved in the TLR-related renal...

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Bibliographic Details
Main Authors: Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, Yau-Sheng Tsai
Format: Article
Language:English
Published: The Company of Biologists 2015-10-01
Series:Disease Models & Mechanisms
Subjects:
Diabetic nephropathy
Toll-like receptor
Tubular injury
Albuminuria
Damage-associated molecular pattern (DAMP)
Online Access:http://dmm.biologists.org/content/8/10/1311

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