Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles

Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles

At the fly neuromuscular junction, postsynaptic receptor perturbation induces homeostatic enhancement of neurotransmitter release. Here, the authors show that the presynaptic proteasome controls a vesicle pool required for homeostatic plasticity and that dysbindin is required to access this pool.

Bibliographic Details
Main Authors: Corinna Wentzel, Igor Delvendahl, Sebastian Sydlik, Oleg Georgiev, Martin Müller
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02494-0
id doaj-f8718c0bcd3242a6a105ee35aaf02555
record_format Article
spelling doaj-f8718c0bcd3242a6a105ee35aaf025552021-05-11T09:47:38ZengNature Publishing GroupNature Communications2041-17232018-01-019111610.1038/s41467-017-02494-0Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesiclesCorinna Wentzel0Igor Delvendahl1Sebastian Sydlik2Oleg Georgiev3Martin Müller4Institute of Molecular Life Sciences, University of ZurichInstitute of Molecular Life Sciences, University of ZurichInstitute of Molecular Life Sciences, University of ZurichInstitute of Molecular Life Sciences, University of ZurichInstitute of Molecular Life Sciences, University of ZurichAt the fly neuromuscular junction, postsynaptic receptor perturbation induces homeostatic enhancement of neurotransmitter release. Here, the authors show that the presynaptic proteasome controls a vesicle pool required for homeostatic plasticity and that dysbindin is required to access this pool.https://doi.org/10.1038/s41467-017-02494-0
collection DOAJ
language English
format Article
sources DOAJ
author Corinna Wentzel
Igor Delvendahl
Sebastian Sydlik
Oleg Georgiev
Martin Müller
spellingShingle Corinna Wentzel
Igor Delvendahl
Sebastian Sydlik
Oleg Georgiev
Martin Müller
Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
Nature Communications
author_facet Corinna Wentzel
Igor Delvendahl
Sebastian Sydlik
Oleg Georgiev
Martin Müller
author_sort Corinna Wentzel
title Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_short Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_full Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_fullStr Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_full_unstemmed Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_sort dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description At the fly neuromuscular junction, postsynaptic receptor perturbation induces homeostatic enhancement of neurotransmitter release. Here, the authors show that the presynaptic proteasome controls a vesicle pool required for homeostatic plasticity and that dysbindin is required to access this pool.
url https://doi.org/10.1038/s41467-017-02494-0
work_keys_str_mv AT corinnawentzel dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles
AT igordelvendahl dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles
AT sebastiansydlik dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles
AT oleggeorgiev dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles
AT martinmuller dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles
_version_ 1721449230921367552

Similar Items