Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors.

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors.

The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species. However, the structural requirements of the respective binding site for...

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Bibliographic Details
Main Authors: Gerhard Rammes, Christine Hosp, Brigitte Eisensamer, Sascha Tanasic, Caroline Nothdurfter, Walter Zieglgänsberger, Rainer Rupprecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2725292?pdf=render

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