Functional Comparison of XPF Missense Mutations Associated to Multiple DNA Repair Disorders
XPF endonuclease is one of the most important DNA repair proteins. Encoded by XPF/ERCC4, XPF provides the enzymatic activity of XPF-ERCC1 heterodimer, an endonuclease that incises at the 5’ side of various DNA lesions. XPF is essential for nucleotide excision repair (NER) and interstrand crosslink r...
Main Authors: | Maria Marín, María José Ramírez, Miriam Aza Carmona, Nan Jia, Tomoo Ogi, Massimo Bogliolo, Jordi Surrallés |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-01-01
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Series: | Genes |
Subjects: | |
Online Access: | http://www.mdpi.com/2073-4425/10/1/60 |
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