RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.

Bibliographic Details
Main Authors:	Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D. Johnson, Michael G. Kharas, Rakez Kayed
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18022-6

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spelling	doaj-f852a7fca4c646d8bcc24eb27d1af2302021-08-29T11:40:16ZengNature Publishing GroupNature Communications2041-17232020-08-0111111610.1038/s41467-020-18022-6RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunctionMauro Montalbano0Salome McAllen1Nicha Puangmalai2Urmi Sengupta3Nemil Bhatt4Omar D. Johnson5Michael G. Kharas6Rakez Kayed7Mitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchSchool of Medicine, University of Texas Medical BranchDivision of Molecular Pharmacology, Memorial Sloan Kettering Institute Cancer CenterMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchThe Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.https://doi.org/10.1038/s41467-020-18022-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed
spellingShingle	Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction Nature Communications
author_facet	Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed
author_sort	Mauro Montalbano
title	RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_short	RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_full	RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_fullStr	RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_full_unstemmed	RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_sort	rna-binding proteins musashi and tau soluble aggregates initiate nuclear dysfunction
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.
url	https://doi.org/10.1038/s41467-020-18022-6
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RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

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