Oxidative stress and endothelial dysfunction correction with ACE inhibitor therapy in patients with myocardial infarction and Type 2 diabetes mellitus

• Main Authors: V. S. Zadionchenko, K. S. Leksina, N. Yu. Timofeeva, G. G. Shekhyan, M. A. Mironova, T. M. Terekhova
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2008-10-01
• Series: Российский кардиологический журнал
• Subjects: myocardial infarction; type 2 diabetes mellitus; oxidative stress; endothelial dysfunction; corrective potential; zofenopril
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/1624

In total, 25 patients with acute myocardial infarction (MI) and 25 patients with MI and Type 2 diabetes mellitus (DM-2) received an ACE inhibitor zofenopril (zocardis) for 6 months, as a part of their basis therapy. Lipid peroxidation and antioxidant system dynamics, endogenous cytoprotective mechanisms - NO and HSP70 stress proteins - were assessed during first 24 hours after hospitalization, as well as 1 and 6 months after MI. Long-term zofenopril therapy was associated with reduced levels of free-radical lipid peroxidation, due to protective antioxidant enzyme activation and increase in serum total antioxidant activity. The medication also improved the parameters ofprotective HSP70 system and endothelial function.