Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptos...

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Main Authors: Ruiqi Cai, Lingyun Wang, Xiong Liu, Marek Michalak, Jingfeng Tang, Ji-Bin Peng, Xing-Zhen Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02521-3
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spelling doaj-f84f1128838c439088a25fe4a20a4f1e2021-08-22T11:14:29ZengNature Publishing GroupCommunications Biology2399-36422021-08-014111310.1038/s42003-021-02521-3Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasionRuiqi Cai0Lingyun Wang1Xiong Liu2Marek Michalak3Jingfeng Tang4Ji-Bin Peng5Xing-Zhen Chen6Department of Physiology, Faculty of Medicine and Dentistry, University of AlbertaDivision of Nephrology, Department of Medicine, Nephrology Research and Training Center, University of Alabama at BirminghamDepartment of Physiology, Faculty of Medicine and Dentistry, University of AlbertaDepartment of Biochemistry, Faculty of Medicine and Dentistry, University of AlbertaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of TechnologyDivision of Nephrology, Department of Medicine, Nephrology Research and Training Center, University of Alabama at BirminghamDepartment of Physiology, Faculty of Medicine and Dentistry, University of AlbertaCai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptosis assays.https://doi.org/10.1038/s42003-021-02521-3
collection DOAJ
language English
format Article
sources DOAJ
author Ruiqi Cai
Lingyun Wang
Xiong Liu
Marek Michalak
Jingfeng Tang
Ji-Bin Peng
Xing-Zhen Chen
spellingShingle Ruiqi Cai
Lingyun Wang
Xiong Liu
Marek Michalak
Jingfeng Tang
Ji-Bin Peng
Xing-Zhen Chen
Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
Communications Biology
author_facet Ruiqi Cai
Lingyun Wang
Xiong Liu
Marek Michalak
Jingfeng Tang
Ji-Bin Peng
Xing-Zhen Chen
author_sort Ruiqi Cai
title Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_short Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_full Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_fullStr Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_full_unstemmed Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_sort auto-inhibitory intramolecular s5/s6 interaction in the trpv6 channel regulates breast cancer cell migration and invasion
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-08-01
description Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptosis assays.
url https://doi.org/10.1038/s42003-021-02521-3
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