Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM.

Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM.

During vertebrate embryogenesis, somites are generated at regular intervals, the temporal and spatial periodicity of which is governed by a gradient of fibroblast growth factor (FGF) and/or Wnt signaling activity in the presomitic mesoderm (PSM) in conjunction with oscillations of gene expression of...

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Bibliographic Details
Main Authors: Shinichi Hayashi, Taiju Shimoda, Masato Nakajima, Yuki Tsukada, Yuichi Sakumura, J Kim Dale, Miguel Maroto, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2680047?pdf=render

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