Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome

Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome

Abstract Introduction Disruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased risk for Alzheimer's disease (AD). Methods...

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Bibliographic Details
Main Authors: Mark Mapstone, Thomas J Gross, Fabio Macciardi, Amrita K Cheema, Melissa Petersen, Elizabeth Head, Benjamin L Handen, William E Klunk, Bradley T Christian, Wayne Silverman, Ira T Lott, Nicole Schupf, for the Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
carbohydrate metabolism
Down syndrome
energy metabolism
fatty acid metabolism
lipid metabolism
Online Access:https://doi.org/10.1002/dad2.12028

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