Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters

Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters

Objective: Familial hypercholesterolemia (FH) is a dominant inherited disease caused mainly by low-density lipoprotein receptor (LDLR) gene mutations. To different extents, both heterozygous and homozygous FH patients develop premature coronary heart disease (CHD). However, most of the experimental...

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Bibliographic Details
Main Authors: Jinjie Wang, Kunxiang He, Chun Yang, Xiao Lin, Xin Zhang, Yuhui Wang, George Liu, Xunde Xian
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
low-density lipoprotein receptor
familial hypercholesterolemia
hamster
dietary cholesterol
atherosclerosis
Online Access:https://www.mdpi.com/1422-0067/20/14/3515

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