Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model

Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model

The current progress using the human embryonic stem cell (hESC) model system has provided much insight into the early origins of the hematopoietic and endothelial lineages, particularly the elusive hemangioblast. Recently, the cellular hierarchy and molecular regulation controlling hematopoietic com...

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Main Authors: Anna Jezierski, Albert Swedani, Lisheng Wang
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2007.310
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spelling doaj-f840691fd0524121a89f4478ff81121b2020-11-25T02:46:55ZengHindawi LimitedThe Scientific World Journal1537-744X2007-01-0171950196410.1100/tsw.2007.310Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a ModelAnna Jezierski0Albert Swedani1Lisheng Wang2Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, CanadaDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, CanadaDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, CanadaThe current progress using the human embryonic stem cell (hESC) model system has provided much insight into the early origins of the hematopoietic and endothelial lineages, particularly the elusive hemangioblast. Recently, the cellular hierarchy and molecular regulation controlling hematopoietic commitment have been further elucidated. These findings not only provide new insights into early human development, but also advance the knowledge required to develop techniques capable of generating a given cell type for potential clinical applications. This review will focus on the latest advances using the hESC model system, capitalizing on the well-established mouse embryonic stem cell model system, as a means to investigate the lineage commitment events underlying the early embryonic development of human hematopoietic and endothelial cells.http://dx.doi.org/10.1100/tsw.2007.310
collection DOAJ
language English
format Article
sources DOAJ
author Anna Jezierski
Albert Swedani
Lisheng Wang
spellingShingle Anna Jezierski
Albert Swedani
Lisheng Wang
Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model
The Scientific World Journal
author_facet Anna Jezierski
Albert Swedani
Lisheng Wang
author_sort Anna Jezierski
title Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model
title_short Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model
title_full Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model
title_fullStr Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model
title_full_unstemmed Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model
title_sort development of hematopoietic and endothelial cells from human embryonic stem cells: lessons from the studies using mouse as a model
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2007-01-01
description The current progress using the human embryonic stem cell (hESC) model system has provided much insight into the early origins of the hematopoietic and endothelial lineages, particularly the elusive hemangioblast. Recently, the cellular hierarchy and molecular regulation controlling hematopoietic commitment have been further elucidated. These findings not only provide new insights into early human development, but also advance the knowledge required to develop techniques capable of generating a given cell type for potential clinical applications. This review will focus on the latest advances using the hESC model system, capitalizing on the well-established mouse embryonic stem cell model system, as a means to investigate the lineage commitment events underlying the early embryonic development of human hematopoietic and endothelial cells.
url http://dx.doi.org/10.1100/tsw.2007.310
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AT albertswedani developmentofhematopoieticandendothelialcellsfromhumanembryonicstemcellslessonsfromthestudiesusingmouseasamodel
AT lishengwang developmentofhematopoieticandendothelialcellsfromhumanembryonicstemcellslessonsfromthestudiesusingmouseasamodel
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