Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages

Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages

Uropathogenic E. coli (UPEC) causes the majority of urinary tract infections (UTIs), which are a major global public health concern. UPEC uses numerous mechanisms to subvert the innate immune system, including targeting macrophage functions. We recently showed that some UPEC strains rapidly kill hum...

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Bibliographic Details
Main Authors: Ambika M. V. Murthy, Minh-Duy Phan, Kate M. Peters, Nguyen Thi Khanh Nhu, Rodney A. Welch, Glen C. Ulett, Mark A. Schembri, Matthew J. Sweet
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
α-hemolysin
cell death
cof
gene regulation
inflammasome
macrophage
UPEC
urinary tract infection
Online Access:http://dx.doi.org/10.1080/21505594.2018.1465786

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