Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Homeostasis of mammalian cell function strictly depends on balancing oxygen exposure to maintain energy metabolism without producing excessive reactive oxygen species. In vivo, cells in different tissues are exposed to a wide range of oxygen concentrations, and yet in vitro models almost exclusively...

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Bibliographic Details
Main Authors: Shengyong Ng, Sandra March, Ani Galstian, Kirsten Hanson, Tânia Carvalho, Maria M. Mota, Sangeeta N. Bhatia
Format: Article
Language:English
Published: The Company of Biologists 2014-02-01
Series:Disease Models & Mechanisms
Subjects:
Hypoxia
Primary hepatocytes
Liver-stage malaria
Online Access:http://dmm.biologists.org/content/7/2/215

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