Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices

Cortical visual processing in visual MT/V5 is necessary for tracking movement and performing reliable visuomotor transformations. Although the role of this cortical area is well recognized, the activity of the visual MT/V5 cortical area in children with cerebral palsy (CP) has not been examined nor...

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Main Authors: Jacy R. VerMaas, James E. Gehringer, Tony W. Wilson, Max J. Kurz
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158219302268
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spelling doaj-f8368b5a87df49dabb2cdbb95950f7112020-11-25T01:11:34ZengElsevierNeuroImage: Clinical2213-15822019-01-0123Children with cerebral palsy display altered neural oscillations within the visual MT/V5 corticesJacy R. VerMaas0James E. Gehringer1Tony W. Wilson2Max J. Kurz3Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, United States of America; Center for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE, United States of AmericaDepartment of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, United States of America; Center for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE, United States of AmericaCenter for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE, United States of America; Department of Neurological Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States of AmericaDepartment of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, United States of America; Center for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE, United States of America; Corresponding author at: Department of Physical Therapy, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198-5450, United States of America.Cortical visual processing in visual MT/V5 is necessary for tracking movement and performing reliable visuomotor transformations. Although the role of this cortical area is well recognized, the activity of the visual MT/V5 cortical area in children with cerebral palsy (CP) has not been examined nor has its potential role in the atypical motor actions of these children been considered. This study used magnetoencephalography to image the neural activity in the motion-sensitive MT/V5 cortices of typically developing (TD) children (n = 21; mean age 14 yrs. ± 2, 12 males) and children with CP (n = 21; mean age 16 yrs. ± 4, 13 males) as they viewed a horizontally moving stimulus. Behavioral measures of visual perception were additionally assessed by having the participants press a button when the visual stimulus changed to moving in vertical direction. Our results showed that the horizontal movement of the visual stimulus evoked changes in the strength of the theta-alpha (5–10 Hz) and alpha-beta (8–20 Hz) oscillations in the visual MT/V5 area of all participants. Compared with the TD children, the children with CP had weaker alpha-beta oscillations in the visual MT/V5 cortices. In addition, the children with CP took longer to perceive a directional change of the visual stimulus and made more errors in detecting the change. Lastly, weaker alpha-beta oscillations were correlated with slower detection of the change in motion direction and less accuracy in identifying the change. This study shows that the uncharacteristic neural oscillations in the visual MT/V5 cortical area may partially account for the abnormal perceptions and motor decisions seen in children with CP. Keywords: Visual perception, Magnetoencephalography, Brain imaging, Visuomotor, Visionhttp://www.sciencedirect.com/science/article/pii/S2213158219302268
collection DOAJ
language English
format Article
sources DOAJ
author Jacy R. VerMaas
James E. Gehringer
Tony W. Wilson
Max J. Kurz
spellingShingle Jacy R. VerMaas
James E. Gehringer
Tony W. Wilson
Max J. Kurz
Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices
NeuroImage: Clinical
author_facet Jacy R. VerMaas
James E. Gehringer
Tony W. Wilson
Max J. Kurz
author_sort Jacy R. VerMaas
title Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices
title_short Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices
title_full Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices
title_fullStr Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices
title_full_unstemmed Children with cerebral palsy display altered neural oscillations within the visual MT/V5 cortices
title_sort children with cerebral palsy display altered neural oscillations within the visual mt/v5 cortices
publisher Elsevier
series NeuroImage: Clinical
issn 2213-1582
publishDate 2019-01-01
description Cortical visual processing in visual MT/V5 is necessary for tracking movement and performing reliable visuomotor transformations. Although the role of this cortical area is well recognized, the activity of the visual MT/V5 cortical area in children with cerebral palsy (CP) has not been examined nor has its potential role in the atypical motor actions of these children been considered. This study used magnetoencephalography to image the neural activity in the motion-sensitive MT/V5 cortices of typically developing (TD) children (n = 21; mean age 14 yrs. ± 2, 12 males) and children with CP (n = 21; mean age 16 yrs. ± 4, 13 males) as they viewed a horizontally moving stimulus. Behavioral measures of visual perception were additionally assessed by having the participants press a button when the visual stimulus changed to moving in vertical direction. Our results showed that the horizontal movement of the visual stimulus evoked changes in the strength of the theta-alpha (5–10 Hz) and alpha-beta (8–20 Hz) oscillations in the visual MT/V5 area of all participants. Compared with the TD children, the children with CP had weaker alpha-beta oscillations in the visual MT/V5 cortices. In addition, the children with CP took longer to perceive a directional change of the visual stimulus and made more errors in detecting the change. Lastly, weaker alpha-beta oscillations were correlated with slower detection of the change in motion direction and less accuracy in identifying the change. This study shows that the uncharacteristic neural oscillations in the visual MT/V5 cortical area may partially account for the abnormal perceptions and motor decisions seen in children with CP. Keywords: Visual perception, Magnetoencephalography, Brain imaging, Visuomotor, Vision
url http://www.sciencedirect.com/science/article/pii/S2213158219302268
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