Contribution of Autophagy-Notch1-Mediated NLRP3 Inflammasome Activation to Chronic Inflammation and Fibrosis in Keloid Fibroblasts

Contribution of Autophagy-Notch1-Mediated NLRP3 Inflammasome Activation to Chronic Inflammation and Fibrosis in Keloid Fibroblasts

Keloid is a representative chronic fibroproliferative condition that occurs after tissue injury. Emerging evidence showed that activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is involved in the pro-inflammatory response in injured tissues. However, the role of NLR...

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Bibliographic Details
Main Authors: Seongju Lee, Sun Kyeon Kim, Hyungsun Park, Yu Jin Lee, Song Hee Park, Kyung Jae Lee, Dong Geon Lee, Hoon Kang, Jung Eun Kim
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
Inflammasome
Keloid
Notch
Autophagy
Online Access:https://www.mdpi.com/1422-0067/21/21/8050

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