UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression

UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression

Chunmei Geng,*,1 Yujin Guo,*,1 Yi Qiao,2 Jun Zhang,3 Dan Chen,1 Wenxiu Han,1 Mengqi Yang,1 Pei Jiang11Institute of Clinical Pharmacy and Pharmacology, Jining First People’s Hospital, Jining Medical University, Jining, People’s Republic of China; 2Department of P...

Full description

Bibliographic Details
Main Authors:	Geng C, Guo Y, Qiao Y, Zhang J, Chen D, Han W, Yang M, Jiang P
Format:	Article
Language:	English
Published:	Dove Medical Press 2019-07-01
Series:	Neuropsychiatric Disease and Treatment
Subjects:	inflammation Dl-3-n-butylphthalide lipopolysaccharide metabolite biomarkers ultra-high-performance liquid chromatography-mass spectroscopy
Online Access:	https://www.dovepress.com/uplc-q-tof-ms-profiling-of-the-hippocampus-reveals-metabolite-biomarke-peer-reviewed-article-NDT

Similar Items

DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation
by: Bingjiang Han, et al.
Published: (2021-06-01)

Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
by: Yajing Chen, et al.
Published: (2019-02-01)

Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice
by: Yanmin Chang, et al.
Published: (2021-02-01)

Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum
by: Junmin Chen, Na Liu, Xiaopeng Wang, Yanying Zhao, Junna He, Lan Yang, Qian Sun, Jing Zhao, Linjing Wang, Lei Chen
Published: (2019-09-01)

Corrigendum: Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
by: Yajing Chen, et al.
Published: (2021-07-01)

Corrigendum: Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice
by: Yanmin Chang, et al.
Published: (2021-06-01)

Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice
by: Chaonan Lv, et al.
Published: (2018-07-01)

DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
by: Muyassar Mamtilahun, et al.
Published: (2021-01-01)

Dl-3-n-Butylphthalide Alleviates Demyelination and Improves Cognitive Function by Promoting Mitochondrial Dynamics in White Matter Lesions
by: Yiwei Feng, et al.
Published: (2021-03-01)

Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis
by: Xiaochao Tian, et al.
Published: (2017-06-01)

Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis
by: Jingyu Xu, et al.
Published: (2021-08-01)

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia
by: Gang Xu, et al.
Published: (2021-03-01)

Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion
by: Zhilin Xiong, et al.
Published: (2017-07-01)

Efficacy and Safety of Adherence to dl-3-n-Butylphthalide Treatment in Patients With Non-disabling Minor Stroke and TIA—Analysis From a Nationwide, Multicenter Registry
by: Zefeng Tan, et al.
Published: (2021-09-01)

Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson’s Disease
by: Huiying Li, et al.
Published: (2021-05-01)

Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging
by: Run-Zhe Liu, et al.
Published: (2017-11-01)

Dl-3-n-Butylphthalide Alleviates Hippocampal Neuron Damage in Chronic Cerebral Hypoperfusion via Regulation of the CNTF/CNTFRα/JAK2/STAT3 Signaling Pathways
by: Wenxian Li, et al.
Published: (2021-01-01)

Dl-3-n-Butylphthalide regulates the Ang-1/Ang-2/Tie-2 signaling axis to promote neovascularization in chronic cerebral hypoperfusion
by: Wenxian Li, et al.
Published: (2019-05-01)

Dl-3-N-Butylphthalide Promotes Angiogenesis in an Optimized Model of Transient Ischemic Attack in C57BL/6 Mice
by: Jiahui Wang, et al.
Published: (2021-09-01)

DL-3-n-butylphthalide improves cerebral hypoperfusion in patients with large cerebral atherosclerotic stenosis: a single-center, randomized, double-blind, placebo-controlled study
by: Dawei Chen, et al.
Published: (2020-05-01)

Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis
by: Wenxian Li, et al.
Published: (2019-08-01)

Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion
by: Meixi Li, et al.
Published: (2020-06-01)

3-N-Butylphthalide (NBP) Attenuates the Amyloid-ß-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-κB Signaling Pathway
by: Hong-Mei Wang, et al.
Published: (2013-07-01)

Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival
by: Baolong Li, et al.
Published: (2021-01-01)

Neuroprotective effect of butylphthalide combined with aspirin and clopidogrel antiplatelet therapy on progressive cerebral infarction
by: Xing-Bing He
Published: (2016-11-01)

Metabolite Profiling and Distribution of Militarine in Rats Using UPLC-Q-TOF-MS/MS
by: Limin Li, et al.
Published: (2020-02-01)

Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke
by: Yun Qian, et al.
Published: (2019-12-01)

Secondary Metabolite Profiling of Curcuma Species Grown at Different Locations Using GC/TOF and UPLC/Q-TOF MS
by: Jueun Lee, et al.
Published: (2014-07-01)

Effects of dl‐3‐n‐butylphthalide on serum lipoprotein‐associated phospholipase A2 and hypersensitive C‐reactive protein levels in acute cerebral infarction
by: Xiao‐Lei Zhang, et al.
Published: (2019-12-01)

Safety and efficacy of early endovascular therapy combined with butylphthalide for acute basilar artery occlusion: a multicenter, prospective cohort study
by: LIU Shuai, et al.
Published: (2021-01-01)

Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells
by: Yihan Hu, et al.
Published: (2015-11-01)

Tongqiao Huoxue Decoction combined with butylphthalide in the treatment of acute ischemic stroke and its effect on VEGF
by: Xin Chen, et al.
Published: (2021-01-01)

Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans
by: Ying Gong, et al.
Published: (2019-07-01)

The Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy After Acute Carbon Monoxide Poisoning
by: Zhang J, et al.
Published: (2020-04-01)

Effect of alprostadil combined with butylphthalide on the serum inflammatory factors and coagulable function in patients with acute ischemic stroke
by: Wen-Zhuo Dai, et al.
Published: (2016-06-01)

Effect of butylphthalide injection on inflammatory factors, neurological factors and hemorheology in patients with acute cerebral infarction
by: Xin-Dong Liu, et al.
Published: (2018-04-01)

Effect of butylphthalide combined with atorvastatin on serum NSE, ANG II, Hcy inflammatory factors and coagulation function indexes in patients with acute cerebral infarction
by: Li Tao, et al.
Published: (2016-11-01)

3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke
by: Chen N, et al.
Published: (2018-12-01)

Neuroprotective effect and mechanism of butylphthalide after cerebral ischemia-reperfusion injury in rats
by: Shan Shan Huang, et al.
Published: (2021-06-01)

Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy
by: Xiaowen Ye, et al.
Published: (2018-07-01)

Cannot write session to /tmp/vufind_sessions/sess_jaab93nmb3q0knbac6h4cn2n9k