Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs

Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs

In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.

Bibliographic Details
Main Authors: Clyde Dapat, Yasushi Suzuki, Reiko Saito, Yadanar Kyaw, Yi Yi Myint, Nay Lin, Htun Naing Oo, Khin Yi Oo, Ne Win, Makoto Naito, Go Hasegawa, Isolde C. Dapat, Hassan Zaraket, Tatiana Baranovich, Makoto Nishikawa, Takehiko Saito, Hiroshi Suzuki
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2010-03-01
Series:Emerging Infectious Diseases
Subjects:
Influenza A virus
H3N2 subtype
zanamivir
amantadine
antiviral drug resistance
viruses
Online Access:https://wwwnc.cdc.gov/eid/article/16/3/09-1321_article
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spelling doaj-f82f10bed03146748587ed5f5de916d82020-11-25T01:02:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-03-0116349349610.3201/eid1603.091321Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral DrugsClyde DapatYasushi SuzukiReiko SaitoYadanar KyawYi Yi MyintNay LinHtun Naing OoKhin Yi OoNe WinMakoto NaitoGo HasegawaIsolde C. DapatHassan ZaraketTatiana BaranovichMakoto NishikawaTakehiko SaitoHiroshi SuzukiIn 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.https://wwwnc.cdc.gov/eid/article/16/3/09-1321_articleInfluenza A virusH3N2 subtypezanamiviramantadineantiviral drug resistanceviruses
collection DOAJ
language English
format Article
sources DOAJ
author Clyde Dapat
Yasushi Suzuki
Reiko Saito
Yadanar Kyaw
Yi Yi Myint
Nay Lin
Htun Naing Oo
Khin Yi Oo
Ne Win
Makoto Naito
Go Hasegawa
Isolde C. Dapat
Hassan Zaraket
Tatiana Baranovich
Makoto Nishikawa
Takehiko Saito
Hiroshi Suzuki
spellingShingle Clyde Dapat
Yasushi Suzuki
Reiko Saito
Yadanar Kyaw
Yi Yi Myint
Nay Lin
Htun Naing Oo
Khin Yi Oo
Ne Win
Makoto Naito
Go Hasegawa
Isolde C. Dapat
Hassan Zaraket
Tatiana Baranovich
Makoto Nishikawa
Takehiko Saito
Hiroshi Suzuki
Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
Emerging Infectious Diseases
Influenza A virus
H3N2 subtype
zanamivir
amantadine
antiviral drug resistance
viruses
author_facet Clyde Dapat
Yasushi Suzuki
Reiko Saito
Yadanar Kyaw
Yi Yi Myint
Nay Lin
Htun Naing Oo
Khin Yi Oo
Ne Win
Makoto Naito
Go Hasegawa
Isolde C. Dapat
Hassan Zaraket
Tatiana Baranovich
Makoto Nishikawa
Takehiko Saito
Hiroshi Suzuki
author_sort Clyde Dapat
title Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
title_short Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
title_full Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
title_fullStr Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
title_full_unstemmed Rare Influenza A (H3N2) Variants with Reduced Sensitivity to Antiviral Drugs
title_sort rare influenza a (h3n2) variants with reduced sensitivity to antiviral drugs
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2010-03-01
description In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
topic Influenza A virus
H3N2 subtype
zanamivir
amantadine
antiviral drug resistance
viruses
url https://wwwnc.cdc.gov/eid/article/16/3/09-1321_article
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